Journal
BRITISH JOURNAL OF GENERAL PRACTICE
Volume 67, Issue 659, Pages E414-E427Publisher
ROYAL COLL GENERAL PRACTITIONERS
DOI: 10.3399/bjgp17X689377
Keywords
breast cancer; chemoprevention; general practice; preventive therapy; primary care; tamoxifen
Categories
Funding
- Cancer Research UK Policy Department [C42785/A17965]
- Cancer Research UK Postdoctoral Fellowship
- Cancer Research UK [13101, 16891, 17965] Funding Source: researchfish
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Background The cancer strategy for England (2015-2020) recommends GPs prescribe tamoxifen for breast cancer primary prevention among women at increased risk. Aim To investigate GPs' attitudes towards prescribing tamoxifen. Design and setting In an online survey, GPs in England, Northern Ireland, and Wales (n = 928) were randomised using a 2 x 2 between-subjects design to read one of four vignettes describing a healthy patient seeking a tamoxifen prescription. Method In the vignette, the hypothetical patient's breast cancer risk (moderate versus high) and the clinician initiating the prescription (GP prescriber versus secondary care clinician [SCC] prescriber) were manipulated in a 1: 1: 1: 1 ratio. Outcomes were willingness to prescribe, comfort discussing harms and benefits, comfort managing the patient, factors affecting the prescribing decision, and awareness of tamoxifen and the National Institute for Health and Care Excellence (NICE) guideline CG164. Results Half (51.7%) of the GPs knew tamoxifen can reduce breast cancer risk, and one-quarter (24.1%) were aware of NICE guideline CG164. Responders asked to initiate prescribing (GP prescriber) were less willing to prescribe tamoxifen than those continuing a prescription initiated in secondary care (SCC prescriber) (68.9% versus 84.6%, P< 0.001). The GP prescribers reported less comfort discussing tamoxifen (53.4% versus 62.5%, P = 0.01). GPs willing to prescribe were more likely to be aware of the NICE guideline (P = 0.039) and to have acknowledged the benefits of tamoxifen (P< 0.001), and were less likely to have considered its off-licence status (P< 0.001). Conclusion Initiating tamoxifen prescriptions for preventive therapy in secondary care before asking GPs to continue the patient's care may overcome some prescribing barriers.
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