Journal
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1397, Issue 1, Pages 25-34Publisher
WILEY
DOI: 10.1111/nyas.13371
Keywords
claudin-4; claudin-15; claudin-19; C-CPE; crystal structure
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Funding
- Uehara Memorial Foundation
- Japan New Energy and Industrial Technology Development Organization (NEDO)
- Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [17K19347, 15H05775, 26440024] Funding Source: KAKEN
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Claudins are four-transmembrane proteins that constitute the backbone of tight junction strands via self-polymerization in the apicolateral membranes of epithelial cells. Together with their cell-cell adhesion function, claudin proteins form the paracellular barrier and/or channels through epithelial cell sheets whose permeability is primarily dependent on the claudin subtype. Recently determined crystal structures of several claudins revealed the unique claudin fold of four transmembrane helices in a left-handed helical bundle with an extracellular beta-sheet domain. Here, we focus on the structural basis of the intermolecular interactions between claudin molecules and between the Clostridium perfringens enterotoxin and its receptor claudins.
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