Journal
BMB REPORTS
Volume 50, Issue 6, Pages 299-307Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2017.50.6.056
Keywords
Mitophagy; human diseases; human physiology; Mitochondria dysfunctions; mitophagy activity
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Funding
- National Research Foundation of Korea [2016R1A2B2008887]
- Medical Research Center grant [2016R1A5A2007009]
- National Research Foundation of Korea [2016R1A5A2007009] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology.
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