Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-017-15926-0
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2011-0013064]
- Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2016M3C7A1947307]
- Bio & Medical Technology Development Program of the NRF - Korean government, MSIP [NRF-2017M3A9F1027323]
- Samsung Medical Center grant [SMO1161491]
- NRF of Korea - Korea government [MSIP-2011-0013064]
- Brain Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2017M3C7A1048092]
- Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) - Ministry of Science ICT and Future Planning [2017M3C7A1048566]
- National Research Foundation of Korea [2017M3C7A1048092, 2017M3C7A1048566, 2011-0013064] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite recent developments in neuroimaging, alterations of brain functional connectivity in major depressive disorder (MDD) patients with suicidal ideation are poorly understood. This study investigated specific changes of suicidal ideation in functional connectivity of MDD patients. Whole brain functional connectivity in 46 patients with MDD (23 with suicidal ideation and 23 without) and 36 age-and gender-matched healthy controls were compared using resting-state functional Magnetic Resonance Imaging (fMRI) analyzed with network-based statistics (NBS) and graph-theoretical methods. Decreased functional connectivity in a characterized sub-network was observed in patients with MDD and suicidal ideation (FDR-adjusted p < 0.05). The sub-network included the regions of the fronto-thalamic circuits in the left hemisphere. The network measures of the left superior frontal gyrus, pars orbitalis (r = -0.40, p = 0.009), left thalamus (r = -0.41, p = 0.009), and right thalamus (r = -0.51, p = -0.002) were shown, through graph theoretical analysis, to be significantly negatively correlated with severity of suicidal ideation. The reduced functional connectivity in left orbitofrontal-both thalamic regions with suicidal ideation in MDD were inversely proportional to the severity of suicidality independent from depression severity. These findings suggest problems with decision-making and information integration in MDD patients with suicidal ideation.
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