Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 100, Issue -, Pages 1-9Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.05.043
Keywords
Ferrocene conjugates; Ferrocene/ferrocenium redox couple; Huisgen 1,3-dipolar cycloaddition; Antiplasmodial studies; Lipophilicity
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Funding
- CSIR, New Delhi [01(2687)12 EMR-II]
- University of Cape Town
- South African Medical Research Council
- South African Research Chairs Initiative of the Department of Science and Technology
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The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied. (C) 2015 Elsevier Masson SAS. All rights reserved.
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