Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 46, Issue -, Pages 62-71Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2017.03.003
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- Faculty of Science at McGill University
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Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship between the material properties of nuclear bodies and their structural and functional consequences. Furthermore, the molecular basis of these condensed phases is beginning to emerge. Here, I review the latest work in this exciting field, highlighting recent advances and new challenges.
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