Journal
CURRENT DERMATOLOGY REPORTS
Volume 6, Issue 2, Pages 94-103Publisher
SPRINGER
DOI: 10.1007/s13671-017-0178-5
Keywords
Microbiome; Skin microbiota; Gut bacteria; Mycobiome; Psoriasis; Psoriatic arthritis
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Funding
- NIH [R01 AR065174, U01 AI119125]
- National Psoriasis Foundation Translational Research Award
- National Psoriasis Foundation Fellowship
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Purpose of Review To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls. Recent Findings Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively under-represented in psoriasis patients relative to healthy individuals. Summary Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.
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