Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-05930-9
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Funding
- Foundation for Fundamental Research on Matter [N0304M]
- European Regional Development Fund
- province of Gelderland (GO-EFRO project) [2009-010034]
- Lung Foundation Netherlands [3.3.11.002]
- Hypatia fellowship from the Radboud University Medical Center
- European Research Council [ERC 336479]
- Career Development Award from the Human Frontier Science Program
- Netherlands Organization for Scientific Research [NWO-ALW VIDI 864.14.001, ICI-024.002.009]
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Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.
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