Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 23, Pages 6492-6496Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701181
Keywords
apoptosis; cancer therapy; iron oxide nanoparticle; lipid hydroperoxide; singlet oxygen
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Funding
- National Science Foundation of China [81571744, 81601489]
- National Basic Research Program of China (863 Program) [2015AA020502]
- Fundamental Research Funds for the Central Universities [20720170065]
- Science Foundation of Fujian Province [2014Y2004]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
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Reactive oxygen species (ROS)-induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial-temporal control of ROS generation, the meticulous participation of light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatment option. An activatable system has been developed that enables tumor-specific singlet oxygen (O-1(2)) generation for cancer therapy, based on a Fenton-like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition. The IO-LAHP NPs are able to induce efficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific O-1(2) generation and subsequent ROS mediated mechanism. This study demonstrates the effectiveness of modulating biochemical reactions as a ROS source to exert cancer death.
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