Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 12, Issue 9, Pages 963-967Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201700189
Keywords
Lewis acids; Mannich reaction; metal-centered chirality; multicomponent reactions; rhodium
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Funding
- National Natural Science Foundation of P. R. China [21572184, 21472154]
- Fundamental Research Funds for the Central Universities [20720160027]
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A highly efficient direct asymmetric three-component Mannich reaction of an N-acylpyrazole, an aldehyde and a primary or secondary amine, was enabled by a rhodium-based Lewis-acid catalyst with metal-centered chirality. Excellent enantioselectivities were achieved for a variety of substrates at a typical catalyst loading of merely 0.5mol% (23examples, up to 98% ee).
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