Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 62, Issue 6, Pages 1426-1438Publisher
SPRINGER
DOI: 10.1007/s10620-017-4567-1
Keywords
Inflammatory bowel diseases; MiRNA; Intestinal epithelial barrier; Immune homeostasis; Autophagy; Diagnosis
Categories
Funding
- National Natural Scientific Foundation of China [81171923]
- State Key Laboratory of Cancer Biology [CBSKL2014Z13]
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Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD. Furthermore, we have also elaborated the promising role of miRNAs in IBD-related cancer prevention and prognosis prediction.
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