Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 44, Pages 5985-5988Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02753b
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Funding
- National Natural Science Foundation of China [21402037]
- Natural Science Foundation of Hebei Province [B2015201175]
- Foundation of Hebei Education Department [QN2014106]
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A strategy for the NHC-catalyzed synthesis of dihydropyridinones and spirooxindoles has been developed via [3+3] annulation reactions of enals or isatin-derived enals with 2-aminoacrylates under oxidative conditions. In this efficient strategy, the 2-aminoacrylates served as nucleophiles. Modifying the standard base switched the carbon-carbon double bond formation from 5,6-positions to 3,4-positions to generate 5,6-dihydropyridinones and 3,4-dihydropyridinones, respectively. Meanwhile, a diverse set of spirooxindole derivatives were also synthesized in good to excellent yields.
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