Journal
BIO-PROTOCOL
Volume 7, Issue 11, Pages -Publisher
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.2311
Keywords
Colorectal cancer; Orthotopic model; Cecum; Ascending colon; Nude mice
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Funding
- NIH [CCSG CA16672]
- Cancer Prevention and Research Institute of Texas [RP150245]
- University of Texas MD Anderson-China Medical University
- Hospital Sister Institution Fund
- Ministry of Science and Technology, International Research-intensive Centers of Excellence in Taiwan (I-RiCE) [MOST 105-2911-I002-302]
- Ministry of Health and Welfare, China Medical University Hospital Cancer Research Center of Excellence [MOHW106-TDU-B-2 12-144003]
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The host microenvironment plays a prominent role in tumor growth, angiogenesis, invasion, metastasis, and response to therapy. Orthotopic tumor model mimics the natural environment of tumor development and provides an effective approach to investigate tumor pathophysiology and develop therapeutic strategies. This protocol describes the technique involving injection of colorectal cancer cell suspension into the intestinal wall of mice to establish an orthotopic colorectal tumor model.
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