Journal
DEVELOPMENTAL CELL
Volume 41, Issue 5, Pages 459-465Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2017.04.021
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Funding
- NIH [R37 HD032443]
- Swiss National Science Foundation [P300P3_158525]
- Swiss National Science Foundation (SNF) [P300P3_158525] Funding Source: Swiss National Science Foundation (SNF)
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Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.
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