Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 359, Issue 11, Pages 1947-1958Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201601137
Keywords
Palladium-nanoparticles; Oxidative annulation; Benzamides; Alkynes; Isoquinolones
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Funding
- DST [SR/NM/NS-1034/2012]
- CSIR
- IIT Madras
- UGC
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A novel method to synthesize isoquinolones via oxidative annulation of N-alkoxy benzamides and alkynes using binaphthyl-stabilized palladium nanoparticles (Pd-BNP) as catalyst has been developed. This methodology affords various isoquinolone derivatives in good to excellent yields with high regioselectivities in the presence of air as oxidant. N-Methoxybenzothioamide was also found to undergo oxidative annulation with alkyne successfully and provided a sulfur analogue of isoquinolones in moderate yields. The Pd-BNP catalyst was easily recovered and reused up to four times without any apparent agglomeration.
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