Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-15505-3
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Funding
- Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI16C1501]
- Korea Health Industry Development Institute (KHDI) - Ministry of Health & Welfare, Republic of Korea [HI15C0001]
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2015M2A2A7A01045177]
- National Research Foundation of Korea (NRF) - Ministry of Education [2016R1D1A1A02936968]
- Kyungpook National University International Graduate Scholarships (KINGS) from Kyungpook National University, Republic of Korea
- National Research Foundation of Korea [2016R1D1A1A02936968] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1. Intradermal injection of MSC-EVs into C57BL/6 mice promoted the conversion from telogen to anagen and increased expression of wnt3a, wnt5a and versican was demonstrated. The first time our results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo.
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