Journal
CANCER
Volume 123, Issue -, Pages 2089-2103Publisher
WILEY
DOI: 10.1002/cncr.30684
Keywords
carcinogen; genetically engineered mice; melanoma; mouse models; ultraviolet (UV) radiation
Categories
Funding
- National Institutes of Health (NIH)/National Cancer Institute (NCI)
- NIH/NCI [K22CA163799, R01CA193711]
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Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. (c) 2017 American Cancer Society.
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