Journal
PROGRESS IN BIOMATERIALS
Volume 6, Issue 1-2, Pages 39-48Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s40204-017-0062-1
Keywords
Electrospinning; Nanofibers; Wound dressing; Response surface
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Active wound dressings play a significant role in burn and chronic wound treatment. In this study, electrospinning process is used to fabricate a novel three-layer active wound dressing based on epsilon-polycaprolactone (PCL), polyvinylalcohol (PVA), and curcumin (CU) as a biologically active compound. The main purpose for developing such a system is to control wound exudates, which remains a challenge, as well as enjoying the anti-bacterial property. Electrospinning process parameters are optimized by response surface methodology to achieve appropriate nanofibrous electrospun mats, and then, a three-layer dressing has been designed in view of water absorbability, anti-bacterial, and biocompatibility characteristics of the final dressing. The results illustrate that a three-layer dressing based on PCL/curcumin containing PVA as a middle layer with optimized thickness which is placed over the incision, absorbs three times exudates in comparison with pristine dressing. Anti-bacterial tests reveal that the dressing containing 16% curcumin exhibits anti-bacterial activity without sacrificing the acceptable level of cell viability.
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