Journal
RSC ADVANCES
Volume 7, Issue 87, Pages 55026-55033Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra12081h
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Funding
- Natural Science Foundation of China [81673351, 31600267]
- Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique, SOA [MBSMAT-2015-05]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2017250, 2016M590667, 2017T100521]
- China Postdoctoral Science Foundation [2016M590667, 2017T100521]
- Taishan Scholar project from Shandong province
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The OSMAC (one strain-many compounds) protocol was used in this study to obtain various metabolites from the mangrove-derived endophytic fungus Penicillium brocae MA-231. As a result, four new thiodiketopiperazine alkaloids, penicibrocazines F-I (1-4), together with two new N-containing p-hydroxyphenopyrrozin derivatives brocapyrrozins A and B (7 and 8) as well as six known alkaloids (5, 6, and 9-12), were identified from the extract of the Czapek culture medium of the fungus. Their structures and absolute configurations were determined through interpretation of their spectroscopic data and by X-ray crystallographic analysis. Compounds 7 and 9 exhibited potent activity against human pathogenic bacterium Staphylococcus aureus with MIC values of 0.125 and 0.5 mg mL(-1), respectively.
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