Journal
RSC ADVANCES
Volume 7, Issue 19, Pages 11420-11427Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25949a
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Funding
- Technology Innovation Program - Ministry of Trade, Industry and Energy (MOTIE, Korea) [10054687]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1A6A3A11934989]
- Public welfare & Safety research program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2015R1D1A1A09060567]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10054687] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A novel graphene quantum dot (GQD)-based nanocarrier labeled with Herceptin (HER) and beta-cyclodextrin (beta-CD) was developed as a promising theranostic candidate for the treatment of breast cancer. Each component of this nanocarrier plays a critical role in providing multiple functions to achieve enhanced anticancer activities. HER provides active targeting to HER2-overexpressed breast cancer to enhance accumulation in the cancer cells. beta-CD provides a site for loading of a hydrophobic anticancer drug, doxorubicin (DOX), via host-guest chemistry. The nanocarriers also provide diagnostic effects due to the blue-color emission of the GQDs. In response to the acidic environment of cancer cells, the GQD-complex degraded rapidly and the DOX was released in a controlled manner to inhibit proliferation of cancer cells. This multi-functional drug delivery system leads to a synergistically enhanced anticancer strategy which provides treatment and diagnosis. The intracellular trafficking results, along with cell viability and confocal laser scanning microscopy, suggest that the GQD-complex offers a viable strategy for HER2-overexpressed breast cancer-targeting drug delivery applications.
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