Journal
BIOCHEMICAL JOURNAL
Volume 474, Issue 10, Pages 1603-1618Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20160759
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Funding
- National Heart, Lung, and Blood Institutes [R01AI029329, R01HI074704]
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The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small RNAs derived from various sources. Emerging evidence demonstrates that Dicer's endonuclease role extends beyond the generation of small RNAs; it is also involved in processing additional endogenous and exogenous substrates, and is becoming increasingly implicated in regulating a variety of other cellular processes, outside of its endonuclease function. This review will describe the canonical and newly identified functions of Dicer.
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