Journal
RSC ADVANCES
Volume 7, Issue 76, Pages 48466-48474Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra10768d
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Funding
- National Natural Science Foundation of P. R. China [81302661]
- Innovation Team Liaoning of P. R. China [LT2015027]
- Foundation from the Project of Education Department of Liaoning province of P. R. China [L2015419]
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Two norditerpenoids (1-2) with unique carbon skeletons, four sesquiterpenoids (3-6) and nine nor-sesquiterpenoids (7-15) were isolated from the leaves of Crataegus pinnatifida and evaluated as possessing antithrombotic activities in vitro/vivo. Their structures with absolute configurations were determined via a combination of spectroscopic data, chemical methods, and quantum-chemical calculations (ECD, NMR, and OR data). Compound 3 showed an inhibitory effect on ADP induced platelet aggregation in vitro, which is mediated through the response to the specific receptor of P2Y(12) by docking results. Compound 3 also clearly prolonged the time to form thrombocytes induced by FeCl3, in the caudal vessels of zebrafish.
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