Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 43, Pages 5806-5809Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02394d
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Funding
- Wellcome Trust
- Medical Research Council (MRC) [MR/L007665/1]
- Medical Research Council (MRC)/Canadian Grant [G1100135]
- SWON alliance
- National Natural Science Foundation of China [81502989]
- National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health [R01AI100560]
- Medical Research Council [MR/L007665/1, G1100135] Funding Source: researchfish
- MRC [G1100135, MR/L007665/1] Funding Source: UKRI
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Crystallographic analyses of the VIM-5 metallo-beta-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of potent B1 MBL inhibitors. The inhibitors potentiate meropenem activity against clinical isolates harboring MBLs.
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