Journal
RSC ADVANCES
Volume 7, Issue 35, Pages 21366-21374Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra28462k
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [31601512]
- Shenzhen University [2016010]
Ask authors/readers for more resources
beta-Lactoglobulin (BLG)-chlorogenic acid (CA) conjugates were generated by a free radical induced grafting method. BLG-CA conjugates showed better antioxidant activities than BLG. The antioxidant activity increased with the increase of CA substitution. The particle sizes of (-)-epigallocatechin-3-gallate (EGCG)-loaded nanoparticles prepared by the anti-solvent method were 110.3, 107.4, and 105.8 nm for BLG, BLG-CA (low), and BLG-CA (high), respectively. The encapsulation efficiencies of EGCG in BLG, BLG-CA conjugate (low), and BLG-CA conjugate (high) nanoparticles were 72.9%, 71.8%, and 73.5%, respectively. The chemical stabilities of EGCG in both BLG-CA nanoparticles were significantly higher than in BLG nanoparticles. BLG-CA conjugate (high) showed better EGCG retention than BLG-CA conjugate (low) in simulated gastrointestinal digestion fluid. Little EGCG was released in both BLG nanoparticles and BLG-CA nanoparticles under simulated gastric digestion. The release of EGCG in BLG-CA nanoparticles was less than that in BLG nanoparticles, indicating that CA conjugating protected BLG from the digestive enzymes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available