Journal
CHINESE CHEMICAL LETTERS
Volume 28, Issue 4, Pages 919-926Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.02.004
Keywords
Plant activator; Systemic acquired resistance; Salicylic acid; Benzotriazole; Virtual screening
Categories
Funding
- National Basic Research Program of China (973 Program) [2010CB126100]
- National High Technology Research and Development Program of China (863 Program) [2011AA10A207]
- Shanghai Leading Academic Discipline Project [B507]
- Fundamental Research Funds for the Central Universities
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Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1'-position and 5'-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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