4.6 Article

TBHP-promoted direct oxidation reaction of benzylic Csp3-H bonds to ketones

Journal

RSC ADVANCES
Volume 7, Issue 25, Pages 15176-15180

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra00352h

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Funding

  1. He'nan Provincial Department of Science and Technology [152300410117]

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A metal-free oxidation system employing tert-butyl hydroperoxide (TBHP) has been developed for selective oxidation of structurally diverse benzylic sp(3) C-H bonds. This low-cost methodology allows for rapid generation of synthetically and biologically valued arylketones in good to excellent yields from readily available alkylarenes and diarylmethanes.

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