Journal
RSC ADVANCES
Volume 7, Issue 72, Pages 45676-45681Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra09442f
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Funding
- Istituto Italiano di Tecnologia
- Grants-in-Aid for Scientific Research [15K18056] Funding Source: KAKEN
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A new generation of fluorescent carbon nano-onions with enhanced solubility in biological media and bright photoluminescence is reported. The nano-onions functionalized with a water soluble boron dipyrromethene dye emit in the far red spectrum with a high quantum yield (Phi(F)) and are suitable for high resolution imaging. The nanoparticles are characterized by a variety of different analytical techniques such as thermogravimetric analysis, dynamic light scattering, zeta potential, electron microscopy, Raman, X-ray photoelectron and fluorescence spectroscopies. They are easily internalized by human breast cancer cells (MCF-7) without any significant toxic effects. Moreover, confocal imaging studies show they exhibit a high fluorescence intensity and are localized in the lysosomes at a very low concentration. Our findings confirm the excellent potentialities of these functionalized carbon nanomaterials as biocompatible platform for high resolution biological imaging.
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