Journal
CHINESE CHEMICAL LETTERS
Volume 28, Issue 4, Pages 893-899Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.01.005
Keywords
Supramolecular organic framework; Doxorubicin; Drug delivery; In situ preparation; Hydrophobicity; Human breast cancer; Controlled release
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Funding
- National Natural Science Foundation of China [21432004, 21529201, 91527301]
- Ministry of Science and Technology of China [2013CB834501]
- Ministry of Education of China
- Molecular Foundry, Lawrence Berkeley National Laboratory
- Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division, of the U.S. Department of Energy [DE-AC02-05CH11231]
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Four water-soluble porous supramolecular organic framework drug delivery systems (sof-DDSs) have been used to adsorb doxorubicin (DOX) in water at physiological pH of 7.4, which is driven exclusively by hydrophobicity. The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water. The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells. DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells. In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors, leading to 13-19-fold reduction of the IC50 values as compared with that of DOX. This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents, and thus should be highly valuable for future development of low-cost delivery systems. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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