Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 25, Pages 7078-7082Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701691
Keywords
homogeneous catalysis; chemoselectivity; Csp(2)-Csp(3) coupling; dimers; palladium
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Funding
- RWTH Aachen
- MIWF NRW
- European Research Council [ERC-637993]
- Evonik
- JARA-HPC from RWTH Aachen University [jara0091]
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Disclosed herein is the first general chemo- and site-selective alkylation of C-Br bonds in the presence of COTf, C-Cl and other potentially reactive functional groups, using the air-, moisture-, and thermally stable dinuclear Pd-I catalyst, [Pd(mu-I)PtBu3](2). The bromo-selectivity is independent of the substrate and the relative positioning of the competing reaction sites, and as such fully predictable. Primary and secondary alkyl chains were introduced with extremely high speed (<5 min reaction time) at room temperature and under open-flask reaction conditions.
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