Journal
RSC ADVANCES
Volume 7, Issue 48, Pages 30177-30184Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra05397e
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Funding
- NIH [R15GM114752]
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This study investigated the photo-activated antibacterial function of a series of specifically prepared carbon dots with 2,2'-(ethylenedioxy)bis(ethylamine) as the surface functionalization molecule (EDA-CDots), whose fluorescence quantum yields (Phi(F)) ranged from 7.5% to 27%. The results revealed that the effectiveness of CDots' photo-activated bactericidal function was correlated with their observed FF values. The antimicrobial activities of these EDA-CDots against both Gram negative and Gram positive model bacterial species (E.coli and Bacillus subtilis, respectively) were also evaluated under conditions of varying other experimental parameters including dot concentrations and treatment times. Optimization of the bactericidal effect of the EDA-CDots by a combination of the selected FF, concentration and treatment time was explored, and mechanistic implications of the results are discussed.
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