4.6 Article

near-infrared phosphorescent iridium(III) complex for imaging of cysteine and homocysteine in living cells and in vivo

Journal

RSC ADVANCES
Volume 7, Issue 83, Pages 52621-52625

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra09798k

Keywords

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Funding

  1. Natural Science Foundation of China [21501031, 51478123, 21463003]
  2. Key Technology R&D Program of Jiangxi Province [20143ACG70019]
  3. Natural Science Foundation of Jiangxi Province of China [20151BAB213001]

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Based on the cyclization reaction of an aldehyde with an aminoalkyl thiol, a novel NIR-emitting iridium(III) complex (NIR-Ir) showed off-on phosphorescent response toward Cys and Hcy, and was developed to detect Cys/Hcy levels in vitro and in vivo.

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