N,N-Dimethylformamide-stabilized copper nanoparticles as a catalyst precursor for Sonogashira-Hagihara cross coupling

We report the catalysis of a Sonogashira-Hagihara cross-coupling reaction using a DMF-stabilized copper nanoparticle catalyst. The reaction proceeded with low catalyst loadings, and a turnover number of 4.0 x 10(3) was recorded for 0.01 mol% catalyst loading. DMF-stabilized copper nanoparticles thus showed high catalytic activity.