Journal
RSC ADVANCES
Volume 7, Issue 26, Pages 15997-16004Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra00954b
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Funding
- National Natural Science Foundation of China [31672071]
- Special Funds of Central Colleges Basic Scientifc Research Operating Expenses [2452015096]
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In continuation of our program to discover new potential natural-product-based crop protection agents, we synthesized a series of 14-formyl-15-aryloxy/methoxymatrine and 14-aryloxymethylidenylmatrine derivatives as pesticidal agents by structural modification of matrine, a biorenewable quinolizidine alkaloid isolated from Sophora flavescens. The structural assignment was based on spectroscopic and X-ray analysis data. Their pesticidal activities were carried out against two typically crop-threatening agricultural insect pests, Mythimna separata Walker and Plutella xylostella Linnaeus. Compounds 4i and 4k exhibited more potent oral toxicity than matrine against 3rd-instar larvae of P. xylostella. As compared with matrine, all derivatives displayed a growth inhibitory property against early 3rd-instar larvae of M. separata, and in particular compounds 4i-k displayed more promising insecticidal activity than toosendanin. Some interesting results of structure-activity relationships were also observed.
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