Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 95, Issue 6, Pages 763-767Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/cjpp-2016-0404
Keywords
resveratrol; JNK/NF-kappa B pathway; spleen lymphocyte; immunosuppressive mice
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Funding
- National Natural Science Foundation of China [31372477]
- International Cooperation Projects of Sichuan Province [2014HH0058]
- Agricultural Technology Research and Development Project of Chengdu [2015-NY02-00266-NC]
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Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and antiinflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different diseases. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor-kappa B (NF-kappa B) pathway and Jun N-terminal kinases (JNK) pathway. The present study aimed to assess immune-enhancing activity and underlying mechanism of resveratrol in immunosuppressive mice. Previously, we reported that resveratrol could promote mouse spleen lymphocyte functions to recover the immune system effectively. In the present study, we show that resveratrol could upregulate the expressions of NF-kappa B, I kappa B kinase, JNK, and c-jun in splenic lymphocytes of immunosuppressive mice. Taken together, our results indicate that resveratrol could promote recovery of immunologic function in immunosuppressive mice by activating JNK/ NF-kappa B pathway.
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