Journal
RSC ADVANCES
Volume 7, Issue 25, Pages 15315-15320Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra00454k
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Funding
- National Nature Science Foundation of China [21175105, 21375104, 21327806]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20126101110015]
- Natural Science Foundation of Shaanxi Province of China [2014JM2050]
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A novel and simple nanopore sensing method has been developed for the detection of Cu-II ions using polyamine decorated cyclodextrin as the recognition element. The strong binding affinity between Cu-II and the amino groups of cyclodextrin inside an a-hemolysin pore causes the new current blockade events. The event frequency is linear for concentrations of Cu-II in the range 0.08-20 mu M. The detection limit is as low as 12 nM. More significantly, the sensing system is highly specific for Cu-II and does not respond to other metal ions with concentrations up to 10 fold that of Cu-II. The applicability of this sensor has also been verified by the analysis of Cu-II ions in running water, suggesting the potential application of this sensing system.
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