Journal
RSC ADVANCES
Volume 7, Issue 6, Pages 3369-3375Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra26048a
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Funding
- National Natural Science Foundation of China [81301316, 31200676]
- China Postdoctoral Science Foundation [2013M540425, 2014T70487, 2015M571705]
- Health and family planning commission of Jiangsu province scientific research subject [H201557]
- Natural Science Foundation of Jiangsu Province [BK20161317]
- Senior Talents Scientific Research Foundation of Jiangsu University [13JDG022, 11JDG113]
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Carbon quantum dots (CDs) as emerging carbon nano-materials have attracted tremendous attention in biomedical fields due to unique properties. In this study, hyaluronate (HA) and polyethylenimine (PEI) functionalized carbon dots (HP-CDs) were synthesized by a facile bottom-up method for tumor targeting and gene delivery. After HA modification, the HP-CDs exhibited superior dispersibility in water and good biocompatibility and were internalized readily into the cytoplasm of cancer via HA-receptor mediated endocytosis. Meanwhile, the HP-CDs with PEI functionalization were shown to have excellent gene condensation capability via electrostatic attraction and protective capacity by preventing nuclease degradation. By virtue of good photoluminescence properties, the HP-CDs as a gene carrier were successfully applied to intracellular imaging and gene delivery. Taken together, the resultant HP-CDs displayed great potential in tumor targeting, intracellular imaging and gene delivery.
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