4.6 Article

Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

Journal

RSC ADVANCES
Volume 7, Issue 1, Pages 132-136

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra26771h

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Funding

  1. EU [685872]
  2. European Research Council (Advanced Grant VERDI
  3. ERC-AdG) [694160]

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A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.

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