Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 23, Pages 20150-20160Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b16425
Keywords
poly(vinylpyrrolidone); hyaluronan; glycoprotein; friction; tears; ocular lubricants; perfluorophenyl azide
Funding
- Johnson & Johnson Vision Care Inc.
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Biomaterials used in the ocular environment should exhibit specific tribological behavior to avoid discomfort and stress-induced epithelial damage during blinking. In this study, two macromolecules that are commonly employed as ocular biomaterials, namely, poly(vinylpyrrolidone) (PVP) and hyaluronan (HA), are compared with two known model glycoproteins, namely bovine submaxillary mucin (BSM) and alpha(1)-acid glycoprotein (AGP), with regard to their nonfouling efficiency, wettability, and tribological properties when freely present in the lubricant, enabling spontaneous adsorption, and when chemisorbed under low contact pressures. Chemisorbed coatings were prepared by means of photochemically triggered nitrene insertion reactions. BSM and AGP provided boundary lubrication when spontaneously adsorbed in a hydrophobic contact with a coefficient of friction (CoF) of similar to 0.03 similar to 0.04. PVP and HA were found to be excellent boundary lubricants when chemisorbed (CoF <= 0.01). Notably, high-molecular-weight PVP generated thick adlayers, typically around 14 nm, and was able to reduce the CoF below 0.005 when slid against a BSM-coated poly(dimethylsiloxane) pin in a tearlike fluid.
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