Journal
ANNALS OF MEDICINE
Volume 49, Issue 6, Pages 470-478Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890.2017.1294258
Keywords
Birth weight; reference percentile; Chinese; twins
Categories
Funding
- National Natural Science Foundation of China [81373069]
- Science and Technology Department of Sichuan Province [2013SZ0179]
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Background: Birth weight percentiles by gestational age are important for assessing prenatal growth and predicting postnatal outcomes of newborns. Several countries have developed nation-specific birth weight references for twins, but China still lacks such references. Methods and results: Birth weight data for twins born between October 2006 and September 2015 were abstracted from the China National Population-based Birth Defects Surveillance System. A total of 54,786 live twin births aged >= 28 weeks of gestation without birth defects were included in the analysis. The LMS method was adopted to generate gestational age-specific birth weight percentiles and curves for male and female twins separately. Significant differences were observed between the current reference and other references developed for Chinese or non-Chinese twins. The neonatal mortality rate in this cohort was 12.3%, and much higher rates at very early gestation weeks were identified in small-for-gestational-age twins grouped by the newly developed reference cutoffs. Conclusions: The established birth weight centiles represent the first birth weight norm for contemporary Chinese twins and can be a useful tool to assess growth of twins in clinical and research settings.
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