Journal
BIOSENSORS & BIOELECTRONICS
Volume 92, Issue -, Pages 654-660Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.10.036
Keywords
TiO2 hollow nanofiber; Sol-gel method; Direct electron transfer; Glucose oxidase; Glucose biosensor
Categories
Funding
- National Natural Science Foundation of China [21165010, 21465014, 21405065, 21465015]
- State Key Laboratory of Electroanalytical Chemistry [SKLEAC201310]
- Young Scientist Foundation of Jiangxi Province [20112BCB23006, 20122BCB23011]
- Foundation of Jiangxi Educational Committee [GJJ13244]
- Natural Science Foundation of Jiangxi Province [20142BAB203010, 20143ACB21016]
- Ministry of Education by the Specialized Research Fund for the Doctoral Program of Higher Education [20133604110002]
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Effective immobilization of enzymes on an electrode surface is of great importance for biosensor development, but it still remains challenging because enzymes tend to denaturation and/or form close-packed structures. In this work, a free-standing TiO2 hollow nanofibers (HNF-TiO2) was successfully prepared by a simple and scalable electrospun nanofiber film template-assisted sol-gel method, and was further explored for glucose oxidase (GOD) immobilization and biosensing. This porous and nanotubular HNF-TiO2 provides a well-defined hierarchical nanostructure for GOD loading, and the fine TiO2 nanocrystals facilitate direct electron transfer from GOD to the electrode, also the strong interaction between GOD and HNF-TiO2 greatly enhances the stability of the biosensor. The as-prepared glucose biosensors show good sensing performances both in O-2-free and O-2-containing conditions with good sensitivity, satisfactory selectivity, long-term stability and sound reliability. The novel textile formation, porous and hierarchically mesostructured nature of HNF-TiO2 with excellent analytical performances make it a superior platform for the construction of high-performance glucose biosensors.
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