Journal
RSC ADVANCES
Volume 7, Issue 19, Pages 11223-11232Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra27539g
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF)
- Fundacao de Empreendimentos Cientificos e Tecnologicos (FINATEC)
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In this study we report on the elaboration and characterization of core-shellmaghemite-gold nanoparticles with the shell modulated for different thicknesses below 2 nm. Gold-shelled maghemite nanoparticles with an average core size of about 9 nm were developed using a single-step protocol involving reduction of Au3+ in the presence of citrate-coated maghemite nanoparticles. Additionally, post-functionalization of the core-shell structures with aluminium phthalocyanine was successfully accomplished, aimed at the production of a material platform for photodynamic therapy. The as-produced samples were structurally, morphologically, magnetically and optically characterized and presented long-term colloidal stability at physiological pH. Impressively, we found the as-produced samples showed good X-ray attenuation properties, making them able to be used as nanoprobes for targeted computed tomography. Moreover, in vitro nanocytotoxicity tests confirmed a superior biocompatibility of the as-produced samples, making them a very promising multi-task platform for in vivo applications.
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