Journal
BRAIN RESEARCH
Volume 1665, Issue -, Pages 1-21Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2017.03.029
Keywords
Brain-derived neurotrophic factor; Neuroprotection; Brain injury
Categories
Funding
- Sparks, London, UK
- Zhejiang Province, China
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Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome. (C) 2017 Elsevier B.V. All rights reserved.
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