Journal
RSC ADVANCES
Volume 7, Issue 23, Pages 13896-13903Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra28408f
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Funding
- National Natural Science Foundation of China [21273001, 20973019, 20903008, 50725208]
- NSFC [20973019, 50831001]
- NSFC for Outstanding Young Talents [507252008, 10825419]
- National Basic Research Program of China [2014CB931802, 2010CB934700, 2009CB623700]
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In this article we present the self-assembly of gold nanorods with DNA double helices into side-by-side and end-to-end structures by the addition of HVA (hepatitis A virus Vall7 polyprotein gene). Between every two gold nanorods, there is a distance of 10.2 nm which agrees with the length of DNA. By observing the change in color with the naked eye or UV-Vis spectral absorbance, HVA concentration can be quantitatively measured. The colorimetric detection has a linear relationship between the UV-Vis spectral absorbance and the concentration, with a detectable range of 0.05 pM to 35 pM. The standard deviation R-2 value was found to be >0.99. This method is simple, time economic and highly sensitive, and a lower limit of detection up to 0.05 pM HVA can be achieved with great selectivity.
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