Transition metal- and organophotocatalyst-free perfluoroalkylation reaction of amino(hetero)aromatics initiated by the complex [(TMEDA)I•I3] and visible light

Radical initiation for the perfluoroalkylation reaction of amino(hetero) aromatics has been accomplished employing the complex [(TMEDA) I.I-3] and visible light. This methodology circumvents the use of metal(organo) catalysts and biologically-relevant substrates are easily substituted with RF moieties employing a mild and environmentally benign radical strategy starting from readily-available perfluoroalkyl iodides RFI.