Journal
RSC ADVANCES
Volume 7, Issue 2, Pages 791-800Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra25244c
Keywords
-
Categories
Funding
- Croatian Science Foundation [IP-2013-11-5596]
Ask authors/readers for more resources
A combination of flow chemistry and batch-based synthetic procedures has been successfully applied to the assembly of novel 4,5-unsaturated L-ascorbic acid series 6a-6n with diverse C-6-substituted 1,2,3-triazole moiety. We report herein the first Cu(I)-catalyzed 1,3-dipolar cycloaddition of azido functionalized L-ascorbic acid derivative and selected alkynes to provide target 1,2,3-triazolyl appended 4,5-didehydro-5,6-dideoxy-L-ascorbic acid library 6a-6n under both micro-flow and batch conditions. Implementation of ultrasound with flow chemistry accelerated hour-scale reaction conditions in batch to the minute range in micro-flow device and considerably improved the yields for the flow syntheses of 6a-6n. Moreover, the synergistic use of microreactor technology and ultrasonic irradiation highlights the sustainable eco-friendly aspect of utilized method.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available