Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 34, Pages 8180-8184Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702060
Keywords
boranes; borylation; C-H activation; electrophilic substitution; Lewis acids
Categories
Funding
- ERC [305868]
- Royal Society
- EPSRC [EP/K039547/1]
- EPSRC [EP/K039547/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K039547/1] Funding Source: researchfish
- European Research Council (ERC) [305868] Funding Source: European Research Council (ERC)
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Activation of N-heterocyclic carbene boranes (NHC center dot BH3) by I-2 enables the metal-free catalytic C-H borylation of heteroarenes with formation of H-2 as the by-product in a process that uses only bench stable precursors. The borylation of indoles using NHC center dot BH3/I-2 produces C2-borylated indoles exclusively in contrast to other catalytic electrophilic C-H borylation methods. Mechanistic studies indicate that this is due to C3 to C2 boron migration facilitated by the absence of exogenous Bronsted bases. Thus this C-H borylation methodology proceeds under sufficiently Bronsted acidic conditions to enable the thermodynamic C2-borylated indole isomer to be formed instead of the C3 borylated-isomer. This demonstrates that electrophilic C-H borylation can be used to access a wider range of borylated regioisomers than reported to date.
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