Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment

Introduction: Mallaw (Malva sylvestris L.) is a medicinal plant who is traditionally being used as an antiulcer, laxative and anti-hemorrhoid, besides of its culinary use as a food in Tunisian cuisine. The present study was carried out to evaluate the protective effect of Malva sylvestris aqueous extract (MSAE) on constipation-induced by loperamide in male Wistar rats. Methods: Rats were divided into six groups of six animals each: Control, Loperamide (LOP), LOP+ yohimbine (2 mg/kg b.w,i.p.) and LOP+ various doses of MSAE (100, 200 and 400 mg/kg b.w,p.o.). The laxative activity was determined based on the weight, frequency and water content of the feces matter. The effects of MSAE were also evaluated on normal gastric emptying and gastro-intestinal transit as well as loperamide-induced serum metabolic parameters changes and colon oxidative stress. Results: The MSAE (100, 200 and 400 mg/kg; b.w, p.o.), significantly reduced loperamide-induced constipation in a dose-dependent manner. Our extract improves also the gastrointestinal motility, mitigates colon lipid peroxidation and H2O2 colon overload, preserve normal antioxidant enzymes activities and non-enzymatic antioxidant levels, as well as provides stability of lipid profile, hepatic (AST and ALT) and renal (urea and creatinine) levels changed by loperamide intoxication. Conclusion: We suggests in the present work that MSAE had a potent effect against Loperamide-induced constipation through in part to an increase of gastrointestinal motility, astimulation of water intestinal secretion as well as its antioxidant properties. (C) 2017 Elsevier Masson SAS. All rights reserved.