Journal
RSC ADVANCES
Volume 7, Issue 58, Pages 36335-36339Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra05576e
Keywords
-
Categories
Funding
- Open Source Drug Discovery (OSDD)
- Council of Scientific and Industrial Research (CSIR), Government of India [OSDD/HCP0001/12FYP/2012-123/Fin/2412]
- Council of Scientific and Industrial Research, Government of India
- Fast Young Scientist Scheme (SERB) of Department of Science and Technology, Government of India [SB/FT/LS322/2012]
- OSDD-CSIR
Ask authors/readers for more resources
Limited efficacy of the BCG (Bacillus Calmette-Guerin) vaccine against adult tuberculosis and the emergence of resistance to existing anti-tuberculosis drugs compel discovery of novel antibiotics against Mycobacterium tuberculosis. Actinomycetes are still an attractive platform for the discovery of new antimicrobials, especially from untapped natural hotspots, despite the belief that they are an exhausted resource after repeated re-discoveries. Herein we report the isolation and identification of chrysomycin A from an actinomycete isolated from a coastal area in Kerala. We show for the first time that it has antimycobacterial activity. It was found to be bactericidal to planktonic and intracellular M. tuberculosis with an MIC of 3.125 mg mL(-1); it is non-hemolytic and has negligible cytotoxicity. The actinomycete that produces chrysomycin A was found to be a Streptomyces sp. through 16S rRNA gene sequencing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available