Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 48, Pages 6424-6427Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03168h
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Funding
- 973 project of China [2013CB733700]
- NNSFC [21671043]
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We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nano-particles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.
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