☆ 4.7 Article

Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe

CHEMICAL COMMUNICATIONS (2017)

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Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 48, Pages 6520-6523

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03050a

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Categories

Chemistry, Multidisciplinary

Funding

  1. 973 Program [2013CB933800]
  2. National Natural Science Foundation of China [21390411, 21535004, 21375080, 21505088]
  3. 973 Program [2013CB933800]
  4. National Natural Science Foundation of China [21390411, 21535004, 21375080, 21505088]

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Lyso-TPFP presents lysosomal targetability and an acidic pH-activatable response toward formaldehyde. Thus, it exclusively visualizes lysosomal formaldehyde and is immune against it in neutral cytosol and other organelles. In addition, two-photon fluorescence imaging endows Lyso-TPFP with the capability of in situ tracking formaldehyde in live cells and animals.

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